The CardioVascular Health Endpoints and Real-world data Tutorial (CV-HEART) tool is a web-based eLearning application developed to enhance your understanding of clinical research and real-world evidence pertaining to anticoagulation treatment and to provide important points to consider when interpreting study design, endpoints, and methodologies. This application provides a didactic overview of three chapters: Chapter 1 discusses study design for anticoagulation treatment; Chapter 2 discusses common endpoints used in clinical studies of anticoagulation treatment; and lastly Chapter 3 discusses some methodological considerations in clinical studies. The module concludes with a checklist, which can be used as a reference when evaluating published clinical studies.