Summary

• INVEGA TRINZA, like INVEGA SUSTENNA (paliperidone palmitate 1-month), utilizes Nano-Particle Technology to improve dissolution of paliperidone palmitate, which is nearly insoluble in water.¹
• INVEGA TRINZA differs from INVEGA SUSTENNA in its higher concentration (312 mg/mL) and larger particle size.²
• Paliperidone is joined with palmitic acid through ester linkage.¹ Paliperidone palmitate particles are dispersed in an aqueous suspension and transformed into smaller paliperidone palmitate nano-particles through particle-size reduction.^1,3 Nano-particles have a greater surface area than the larger original particles, which results in greater water solubility.¹ Following administration, free paliperidone is slowly released through hydrolysis by esterases in the muscle. Paliperidone is then absorbed into the systemic circulation.¹

LITERATURE SEARCH

A literature search of MEDLINE^®, EMBASE^®, BIOSIS Previews^®, and DERWENT Drug File (and/or other resources, including internal/external databases) pertaining to this topic was conducted on 16 February 2024.