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What is the half-life of INVEGA SUSTENNA? How long does it take for a dose of INVEGA SUSTENNA to be removed from the body?

• Be sure that you read, understand, and follow the FDA-approved patient labeling before you use INVEGA SUSTENNA.¹ Talk to your healthcare provider or pharmacist if you have  any questions.
• After receiving an injection of INVEGA SUSTENNA, the release of the drug starts as early  as day 1 and lasts as long as 126 days.¹
• Half-life is defined as the time it takes for 50% of the drug to be removed from the body. After 5 half-lives (calculated by multiplying the half-life value by 5), about 97% of the drug should be removed from the body.
• The median (“middle”) apparent half-life of paliperidone, the active ingredient in INVEGA  SUSTENNA, following a single-dose administration over the dose range of
  39 mg-234 mg   ranged from 25 days-49 days.¹ The half-life for an individual may not fall exactly within this range. Since these are median values, the half-life may be longer or shorter. The median is the half-way point in the range, so 50% of individuals will have half-lives longer than the median and 50% will have half-lives shorter than the median.
• The time it takes for the drug to be fully removed from the body depends on the dose you are taking-the higher the dose, the longer it will take for drug removal. The time also depends on various other factors, including the body’s ability to remove the drug. Since this is a complex answer that depends on many specific patient factors and can vary from one person to another, share any concerns with your  healthcare provider or pharmacist.

additional information

This information is provided ONLY in response to your request and is not intended as medical advice, to promote the use of our product, or suggest using it in any manner other than as described in the PRESCRIBING INFORMATION. All decisions regarding your medical treatment should be made with your healthcare professional(s). Please contact your healthcare professional(s) to discuss the information in this response.

Please refer to the attached full PRESCRIBING INFORMATION and the PATIENT MEDICATION GUIDE for INVEGA SUSTENNA.¹