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ERLEADA®

(apalutamide)

This information is intended for US patients and caregivers to access current scientific information about Janssen products. It is prepared by Janssen Medical Information and is not intended to promote the use of our products, nor to provide medical advice.

What is ERLEADA?

Last Updated: 07/13/2023

summary

What IS ERLEADA?1

ERLEADA is a prescription medicine used for the treatment of prostate cancer:

  • that has spread to other parts of the body and still responds to a medical or surgical treatment that lowers testosterone, OR
  • that has not spread to other parts of the body and no longer responds to a medical or surgical treatment that lowers testosterone.
  • It is not known if ERLEADA is safe and effective in females.

It is not known if ERLEADA is safe and effective in children.

How does ERLEADA work?

  • ERLEADA works by blocking androgens from attaching to androgen receptors to help prevent cancer cells from growing.1
    • Androgens are male hormones, primarily testosterone, that are needed for the prostate to function normally.2
    • However, when androgens attach to androgen receptors, they can help fuel prostate cancer cell growth.2
  • Androgen deprivation therapy (ADT), which can include medical or surgical treatments, is used to suppress or block the production or action of androgens. However, in certain cases, the prostate cancer adapts to the low levels of androgen.2, 3
  • ERLEADA and ADT work together to lower androgens that can help fuel the prostate cancer. 1, 2

additional information

This information is provided ONLY in response to your request and is not intended as medical advice, to promote the use of our product, or suggest using it in any manner other than as described in the PRESCRIBING INFORMATION. All decisions regarding your medical treatment should be made with your healthcare professional(s). Please contact your healthcare professional(s) to discuss the information in this response.

Please refer to the attached full PRESCRIBING INFORMATION and the PATIENT INFORMATION for ERLEADA.1

References

1 ERLEADA (apalutamide) [Prescribing Information]. Horsham, PA: Janssen Products, LP; https://www.janssenlabels.com/package-insert/product-monograph/prescribing-information/ERLEADA-pi.pdf.
2 National Cancer Institute. Hormone therapy for prostate cancer. In: Cancer.gov [Internet]. Bethesda (MD): National Institutes of Health. 2019- [cited 2023 July 13]. Available from: https://www.cancer.gov/types/prostate/prostate-hormone-therapy-fact-sheet.
3 American Cancer Society. Hormone therapy for prostate cancer. Accessed July 13, 2023. Available from: https://www.cancer.org/cancer/prostate-cancer/treating/hormone-therapy.html.